On a desolate stretch of desert highway, weary travelers - two men on the run from their past, a band on their way to the next gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation - are forced to confront their worst fears and darkest secrets in a series of interwoven tales of terror and remorse on the open road.

Scott Pilgrim plays in a band which aspires to success. He dates Knives Chau, a high-school girl five years younger, and he hasn't recovered from being dumped by his former girlfriend, now a success with her own band. When Scott falls for Ramona Flowers, he has trouble breaking up with Knives and tries to romance Ramona. As if juggling two women wasn't enough, Ramona comes with baggage: seven ex-lovers, with each of whom Scott must do battle to the death in order to win Ramona.